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Safe-Guard (fenbendazole) Paste 10% contains the active anthelmintic, fenbendazole. The chemical name of fenbendazole is methyl 5-(phenylthio)-2-benzimidazole carbamate.
Each gm of Safe-Guard Paste 10% contains 100 mg of fenbendazole and is flavored with artificial apple-cinnamon liquid.
Actions: The antiparasitic action of Safe-Guard Paste 10% is believed to be due to the inhibition of energy metabolism in the parasite.
Indications:
Horse: Safe-Guard Paste 10% is indicated for the control of large strongyles (Strongylus edentatus, S. equinus, S. vulgaris), encysted early 3rd stage (hypobiotic), late 3rd stage and 4th stage cyathostome larvae, small strongyles, pinworms (Oxyuris equi), ascarids (Parascaris equorum), and arteritis caused by 4th stage larvae of Strongylus vulgaris in horses.
Safe-Guard Paste 10% is approved for use concomitantly with an approved form of trichlorfon. Trichlorfon is approved for the treatment of stomach bots (Gasterophilus spp.) in horses. Refer to the manufacturer's label for directions for use and cautions for trichlorfon.
Beef and Dairy Cattle: Safe-Guard Paste 10% is indicated for the removal and control of: Lungworm (Dictyocaulus viviparus); Stomach worms: (Haemonchus contortus, Ostertagia ostertagi, Trichostrongylus axei); Intestinal worms: (Bunostomum phlebotomum, Nematodirus helvetianus, Cooperia punctata & C. oncophora, Trichostrongylus colubriformis, Oesophagostomum radiatum).
Treats 8 animals of 500 lb. each. Net Wt. 3.2 oz. (92g).
Dosage:
Horse: Safe-Guard Paste 10% is administered orally at a rate of 2.3 mg/lb. (5 mg/kg) for the control of large strongyles, small strongyles, and pinworms. Each mark on the plunger rod corresponds to a dose of 5 mg/kg (2.3 mg/lb.) for 250 lb. body weight. For foals and weanlings (less than 18 months of age) where ascarids are a common problem, the recommended dose is 4.6 mg/lb. (10 mg/kg) or two marks will deworm a 250 lb. horse. For control of encysted early 3rd stage (hypobiotic), late 3rd stage and 4th stage cyathostome larvae and 4th stage larvae of Strongylus vulgaris, the recommended dose is 4.6 mg/lb. (10 mg/kg) daily for 5 consecutive days; administer two marks for each 250 lb. body weight per day.
Beef and Dairy Cattle: Safe-Guard Paste 10% is administered orally at a rate of 2.3 mg/lb. (5 mg/kg) or 11.5 g Safe-Guard (fenbendazole) Paste for 500 lb. body weight (227 kg). Under conditions of continuous exposure to parasites, retreatment may be needed after 4 - 6 weeks.
Precautions: Horse: Side effects associated with Safe-Guard Paste 10% could not be established in well-controlled safety studies in horses with single doses as high as 454 mg/lb. (1,000 mg/kg) and 15 consecutive daily doses of 22.7 mg/lb. (50 mg/kg). At higher dose levels, the lethal action of fenbendazole may cause the release of antigens by the dying parasites. This phenomenon may result in either a local or systemic hypersensitive reaction varying in severity from itching or a rash to increased respiration and collapse. A veterinarian should be consulted if this type of reaction is suspected.
Safe-Guard Paste 10% has been evaluated for safety in pregnant mares during all stages of gestation with doses as high as 11.4 mg/lb. (25 mg/kg) and in stallions with doses as high as 11.4 mg/lb. (25 mg/kg). No adverse effects on reproductivity were detected. The recommended dose for control of 4th stage larvae of Strongylus vulgaris, 4.6 mg/lb. (10 mg/kg) daily for 5 consecutive days, has not been evaluated for safety in stallions or pregnant mares.
Merck 34656 Manual