An Osphos (Clodronate) Injection can be given to horses ages 4 years and older. Veterinarians may prescribe Osphos to help treat navicular syndrome. This medication relieves symptoms and helps slow disease progression by preventing bone resorption. Osphos injections are ready to use and do not require dilution. Sold in 15 mL vials.How it Works

Osphos works by inhibiting resorption of bone. It exerts direct effects on the cells of osteoclasts and binds to calcium phosphate crystals. This inhibits their dissolution and formation.

Special Precautions

Keep away from children.

Overdose Information

Immediately contact your closest emergency animal hospital or vet.

Side Effects

Field studies have shown that the most frequently-reported adverse reactions, which occurred within 2 hours of treatment, were:

• Colic
• Pawing
• Cramping
• Nervousness
• Discomfort

After hand walking for 10-15 minutes, 8 out of the 10 horses with the symptoms listed above experience clinical sign resolution. One horse experienced resolution without any hand walking. Just one underwent treatment for colic. That particular horse also experienced hives, recovering following dexamethasone and flunixin treatment.

Storage

Store in a dry and cool environment.

Tips

OSPHOS is administered at 1.8 mg/kg by intramuscular injection up to a maximum dose of 900 mg per horse (one vial). Divide the total volume evenly into three separate injection sites. Discard unused vial contents. OSPHOS is provided in a single use vial and does not contain a preservative. If there is no response to initial therapy, the horse should be re-evaluated. For horses that initially respond to OSPHOS but do not maintain their clinical improvement for 6 months, OSPHOS may be re-administered at 3 to 6 month intervals based on recurrence of clinical signs. For horses that respond to OSPHOS and maintain clinical improvement for 6 months, OSPHOS should be re-administered after clinical signs recur.