Simparica Trio is the #1 vet-prescribed combo preventative.¹ Once monthly liver-flavored chew provides dogs all-in-one protection against heartworm disease, ticks, fleas, flea tapeworms, roundworms, and hookworms. It's approved for puppies as young as eight weeks old and weighing at least 2.8 pounds. Simparica Trio kills fleas before they can lay eggs. In studies, it starts killing fleas within 4 hours with 100% effectiveness in 8 hours. It was the first combination preventative FDA-approved to kill six types of ticks including the deer tick that may carry Lyme infections. It can be given with or without food and is loved by dogs with a study showing 9 out of 10 dogs voluntarily consumed.² Over 15 million dogs have been protected by Simparica Trio.³ Ask your vet if Simparica Trio is right for your dog or puppy. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn't providing sufficient protection, please call Zoetis' medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Enrolling in auto ship provides savings, convenience, and the peace of mind that your dog never misses a dose. Simparica Trio is eligible for Zoetis Petcare Rewards Program. Sign up for free to earn points on every dollar spent on eligible purchases that can be redeemed for services at your vet. Learn more by visiting ZoetisPetcare.com/Rewards.

How it Works

Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in arthropods. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

Special Precautions

Not for human use. Keep away from children and animals. The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Prior to administration of SIMPARICA TRIO dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms.

References

*As a direct result of killing deer ticks.
References: ¹ Data on file. Kynetec PetTrak US FTH National, 2025. ² Study A161C-US-15-634. Data on file. Zoetis Inc. ³ Simparica Trio - 15M Dogs and Counting, PetTrak Kynetec Veterinary Channel Review Q4, 2024.