Simparica Trio Chewable Tablets for Dogs
Item # 254458799
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This item requires prescription approval.
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Item # 254458799
Rx
This item requires prescription approval.
Fulfilled by
Autoship
Save 50% on your first Rx Autoship order, up to $60.
Save 5% on Autoship future orders.Convenient deliveries on a schedule you chooseFree shipping on RX orders over $30No commitment easily cancel anytimeOne Time Purchase
Save 40% on a single order, up to $25
Pet Breed Size: Select a Pet Breed Size
Months Supply: Select a Months Supply
Please make required selection
Neighbor’s Club Members earn points with purchases.
Simparica Trio is the #1 vet-prescribed combo preventative.1 Once monthly liver-flavored chew provides dogs all-in-one protection against heartworm disease, ticks, fleas, flea tapeworms, roundworms, and hookworms. It's approved for puppies as young as eight weeks old and weighing at least 2.8 pounds. Simparica Trio kills fleas before they can lay eggs. In studies, it starts killing fleas within 4 hours with 100% effectiveness in 8 hours. It was the first combination preventative FDA-approved to kill six types of ticks including the deer tick that may carry Lyme infections. It can be given with or without food and is loved by dogs with a study showing 9 out of 10 dogs voluntarily consumed.2 Over 15 million dogs have been protected by Simparica Trio.3 Ask your vet if Simparica Trio is right for your dog or puppy. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn't providing sufficient protection, please call Zoetis' medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Enrolling in auto ship provides savings, convenience, and the peace of mind that your dog never misses a dose. Simparica Trio is eligible for Zoetis Petcare Rewards Program. Sign up for free to earn points on every dollar spent on eligible purchases that can be redeemed for services at your vet. Learn more by visiting ZoetisPetcare.com/Rewards.
How it Works
Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in arthropods. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
Special Precautions
Not for human use. Keep away from children and animals. The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Prior to administration of SIMPARICA TRIO dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms.
References
*As a direct result of killing deer ticks.
References: 1 Data on file. Kynetec PetTrak US FTH National, 2025. 2 Study A161C-US-15-634. Data on file. Zoetis Inc. 3 Simparica Trio - 15M Dogs and Counting, PetTrak Kynetec Veterinary Channel Review Q4, 2024.
- Don't Just Protect, Triple Protect: Simparica Trio is a monthly chew that protects against three categories of parasites including heartworms, ticks & fleas, and intestinal worms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.
- Heartworm Protection: One dose provided 100% protection against heartworm disease in studies to support FDA-approval.
- Kills 6 Types of Ticks & FDA- Approved to Prevent Lyme Infections*: The first combo preventative FDA approved to kill six types of ticks including the Gulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick, and Asian Longhorned Tick.
- Kills Fleas & Intestinal Worms: Prevents flea infestations because it kills fleas before they lay eggs. Prevents tapeworms because it kills fleas. Treats and controls roundworms and hookworms.
- Satisfaction Guaranteed: Simparica Trio comes with a 100% satisfaction guarantee on prevention and is administered once a month, with or without food.
Active Ingredients: Sarolaner, Moxidectin, Pyrantel
Dosage and Administration: The recommended minimum dosage is 1.2 mg/kg (0.54 g/lb.) sarolaner, 24 ug/kg (0.011 mg/lb.) moxidectin, and 5 mg/kg (2.27 mg/lb.) pyrantel (as pyrantel pamoate). SIMPARICA TRIO is given orally on a monthly basis. SIMPARICA TRIO needs to be administered every 4 weeks in case of exposure to Amblyomma maculatum, Dermacentor variabilis, and Rhipicephalus sanguineus. In case of tick infestation, accurate tick identification is recommended prior to administering the product. SIMPARICA TRIO can be offered to the dog with or without food. Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a monthly dose is missed, give immediately and resume monthly dosing.
| Weight (lb.) | Sarolaner per Tablet (mg) | Moxidectin per Tablet (mg) | Pyrantel per Tablet (mg) | Number of Tablets Administered |
|---|---|---|---|---|
| 2.8 to 5.5 lb. | 3.0 | 0.06 | 12.5 | 1 |
| 5.5 to 11 lb. | 6.0 | 0.12 | 25 | 1 |
| 11-22 lb. | 12 | 0.24 | 50 | 1 |
| 22-44 lb. | 24 | 0.48 | 100 | 1 |
| 44-88 lb. | 48 | 0.96 | 200 | 1 |
| 88-132 lb. | 72 | 1.44 | 300 | 1 |
| Brand | Simparica Trio |
|---|---|
| Country of Origin | Made in USA |
| Active Ingredients | 1.2 mg/kg (0.54 g/lb.) sarolaner, 24 ug/kg (0.011 mg/lb.) moxidectin, and 5 mg/kg (2.27 mg/lb.) pyrantel (as pyrantel pamoate) |
| Animal Type | Dog |
| Life Stage | Adult |
| Manufacturer Brand | Zoetis |
| Product Use | Medicine |
| Sold By | Other |
| Manufacturer Part Number | 51631-7 |
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