Legend (Hyaluronate Sodium) Injectable Solution helps cushion and restore joints, and is safe for use in horses. It also offers anti-inflammatory effects. Legend is clear with a low viscosity and is pyrogen free and sterile. Legend may be administered intravenously or by intra-articular injection into the carpus or fetlock as needed. Comes in a 4 mL vial of injectable solution.How it Works

LEGEND® (hyaluronate sodium) Injectable Solution contains the conjugate acid hyaluronic acid which is a naturally occurring substance found in high concentrates in the synovial fluid. Hyaluronic acid regulates normal cellular constituents, exerting anti-inflammatory action and when directly injected into the joint helps restore lubrication of the joint fluid.

Special Precautions

Radiographic evaluation should be carried out in cases of acute lameness to ensure that the joint is free from serious fractures. As with any intra-articular (LEGEND Injectable Solution - 2 mL only) treatment, special precautions must be followed as to injection technique and sterility for prevention of possible swelling or infection. Intra-articular injections should not be made through skin that has been recently fired or blistered, or that has excessive scurf and counterirritant on it. The safety of LEGEND Injectable Solution and LEGEND Multi Dose Injectable Solution has not been evaluated in breeding stallions or in breeding, pregnant or lactating mares.

Overdose Information

Immediately contact your closest emergency animal hospital or vet.

Side Effects

No local or systemic side effects were observed in the field studies using LEGEND intravenously. The following adverse reactions were reported in voluntary post-approval reporting: occasional depression, lethargy, and fever. The following adverse reactions have been reported following use of intra-articular LEGEND Injectable Solution (2 mL only) use: lameness, joint effusion, joint or injection site swelling, and joint pain.

Storage

Store at or below 77° F (25° C). Brief excursions to 104° F (40° C) are permitted.

Tips

The joint fluid contains high concentrations of hyaluronate, and it also occurs naturally within the body. The hyaluronate in this medication is believed to help regulate joint cells that can increase inflammation. After injection into the joint, hyaluronate works to help the joint lining heal and increases the joint fluid thickness. This fluid works to cushion and lubricate the joints, protecting the lining.