Estradiol is commonly used to induce estrus (heat) or estrous behavior in horses. This estrogen hormone drug can also be used for the long-term treatment of estrogen-responsive urinary incontinence. Sometimes dogs and cats may take Estradiol to help avoid pregnancy, as well. Follow veterinarian instructions for safe use. These tablets are sold individually.How it Works

Estradiol is estrogen, which is a hormone that, upon elevation, starts estrus in horses.

Special Precautions

• Like all medications, this should be kept away from children.
• Federal law requires that this drug may only be used by or as directed by a licensed veterinarian.
• Use of this medication in food animals is illegal.

Overdose Information

Immediately contact your closest emergency animal hospital or vet.

Side Effects

Estradiol has a high risk of causing endometrial hyperplasia and pyometra. There is a dose-dependent risk of bone marrow toxicity in animals, particularly in dogs. Estradiol cypionate injections have produced leukopenia, thrombocytopenia, and fatal aplastic anemia. Because stem cells can be affected, the bone marrow toxicity may not be reversible. These adverse effects can be severe, and other agents should be used instead of estradiol cypionate if possible.

Storage

Store at room temperature of 59°-86°F (15°-30°C).

Tips

Estradiol is the most active endogenous estrogen. It increases water and sodium retention, has a slight anabolic effect, increases calcium deposition in the bones, accelerates epiphyseal closure, and is responsible for secondary sexual characteristic development.