Trusted by veterinarians, the Zymox Shamp 12oz Vitamin D3 Shampoo is designed for pets with itchy inflamed skin or surface irritations. This easy-to-use shampoo can be used on all animals, including dogs, cats, and exotics of any age. It features the LP3 Enzyme System with the addition of Vitamin D3 and Vitamin E to help soothe dry and itchy skin. Only the mildest plant surfactants are used for a gentle and tear free wash experience for your pet. First, wet animal thoroughly with water. Then apply the ZYMOX Shampoo on the entire animal, concentrating on problem areas. Leave lather on for 3 to 5 minutes, then rinse. Use twice a week or until symptoms subside. for best results, follow with ZYMOX Conditioning Rinse with Vitamin D3. This product is proudly made in the USA..