Zycosan Pentosan Polysulfate Sodium Injection is indicated for the control of clinical signs associated with osteoarthritis, inflammation or degenerative joint disease, this Pentosan Polysulfate injection works to preserve cartilage integrity, helping to improve joint health and reduce pain. The injection should only be administered intramuscularly. Sold as an individual 7.5 mL vial with 250 mg/mL of Pentosan Polysulfate.How it Works

Pentosan Polysulfate, or PPS, is a semi-synthetic polysaccharide ester that is similar to heparin. Derived from the hemicellulose of beechwood, PPS is considered a mild anticoagulant. It has hypolipidemic, fibrinolytic, and anti-inflammatory qualities. PPS is useful in managing and treating osteoarthritis. It is believed to aid in preserving the integrity of cartilage, improving the health of the joints by supporting the anabolic activity of synoviocytes and chondrocytes. It protects against catabolic events in the joints because it reduces cytokine levels and inflammatory mediators in the synovial fluid and cartilage matrix.

Special Precautions

Keep away from children and animals. As with all drugs, side effects may occur. For intramuscular use in horses only. Not for use in humans. Pentosan polysulfate sodium is a weak anticoagulant. Caution should be used when administering Zycosan if you are taking an anticoagulant. In case of accidental self-injection, seek immediate medical attention. If product comes into contact with skin, rinse skin thoroughly with water and seek medical attention if needed. Horses with hypersensitivity to pentosan polysulfate sodium should not receive Zycosan. Do not use Zycosan concurrently with other anticoagulant drugs. Do not use in horses with clotting disorders or within 24 hours of surgical procedures. Caution should be used when administering this drug before or after strenuous activities. Caution should be used when NSAIDS are administered concurrently due to the anticoagulant effects of Zycosan. If Zycosan and NSAIDS are used concurrently, horses should be monitored for hemorrhage or other clinical signs of abnormal bleeding. The safe use of Zycosan has not been evaluated in breeding, pregnant, or lactating horses. The safety of long-term repeat use of Zycosan has not been evaluated.

Overdose Information

Immediately contact your closest emergency animal hospital or vet.

Side Effects

The most frequently reported adverse reactions are injection site reactions, prolongation of coagulation parameters (activated partial thromboplastin time (aPTT) and prothrombin time (PT).

Storage

Store at room temperature 68-77°F (20-25°C) with excursions between 59-86°F (15-30°C) permitted.