Credelio Quattro Chewable Tablet for Dogs and Puppies, available in beef-flavored chews, is indicated for the prevention of heartworm disease and the treatment and control of roundworms, hookworms, and tapeworms. It also provides effective control of adult fleas and is used for the treatment and prevention of flea infestations. Additionally, Credelio Quattro is indicated for the treatment and control of tick infestations, including those caused by the lone star tick, American dog tick, black-legged tick, and brown dog tick.How it Works

Credelio Quattro contains four active pharmaceutical ingredients, lotilaner, moxidectin, praziquantel, and pyrantel (as pamoate salt). Lotilaner is an ectoparasiticide belonging to the isoxazoline group. Lotilaner inhibits insect and acarine gamma-aminobutyric acid (GABA)-gated chloride channels. This inhibition blocks the transfer of chloride ions across cell membranes, which results in uncontrolled neuromuscular activity leading to death of insects and acarines. The selective toxicity of lotilaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines' GABA receptors versus mammalian GABA receptors. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Praziquantel's mode of action is not precisely known, but treated tapeworms undergo muscular paralysis accompanied by a rapid influx of calcium ions and the disruption of the tegument. Pyrantel is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, causing paralysis and death or expulsion of the parasite.

Special Precautions

Not for use in humans. Keep this and all drugs out of reach of children. Wash hands after handling. See packaging insert or label for full precautions.

Overdose Information

Contact the nearest emergency animal hospital

Side Effects

Possible side effects may include: diarrhea, vomiting, lethargy, anorexia, dermatitis, weight loss, itching or alopecia.

Storage

Store at 15-25 °C (59-77 °F). Excursions permitted between 5 and 40 °C (41 and 104 °F).