Proin 

As dog owners, our main priority is to help our four-legged companions live confidently, comfortably and happily. PROIN is a trusted solution for dogs experiencing urinary incontinence (the loss of bladder control). With a focus on effective, veterinarian-prescribed care, PROIN gives families greater peace of mind and a solution for managing unexpected leaks, allowing dogs to enjoy Life Out Here freely. Tractor Supply believes every dog deserves to feel its best every day, which is why we proudly carry PROIN medications. 

Important Safety Information from PROIN

*Kendall A, et al. ACVIM consensus statement on diagnosis and management of urinary incontinence in dogs. J Vet Intern Med. 2024

**Source: PRN Market Survey, May 2026

***when administered as prescribed

****based on documented MAP pricing. Price may vary by SKU/strength and package size. Actual pet owner price may vary.

PROIN ER™ IMPORTANT SAFETY INFORMATION

For oral use in dogs only. Not for human use. Keep out of reach of children. If accidentally ingested by humans, contact a physician immediately. 

The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases death, including euthanasia has been reported. Sudden death was sometimes preceded by vocalization or collapse. 

Instances of dogs chewing through closed vials of PROIN® and eating the vial contents have been reported, in some cases resulting in overdose. Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN ER™ tablets. Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN ER™ tablets.

PROIN ER™ may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure. Dogs may transition from PROIN® Chewable Tablets to PROIN ER™ without a break in administration. However, do not alternate PROIN ER™ with PROIN® Chewable Tablets because effectiveness and safety of interchangeable use has not been evaluated.

The safe use of PROIN ER™ in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions.

PROIN ER Approved by FDA under NADA #141-517

PROIN® IMPORTANT SAFETY INFORMATION

The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases, death, including euthanasia, has been reported. Sudden death was sometimes preceded by vocalization or collapse.

Instances of dogs chewing through closed vials of PROIN® and eating the vial contents have been reported, in some cases resulting in overdose. Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN® Chewable tablets. Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN® Chewable tablets.

PROIN® may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure.

The safe use of PROIN® in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions.

PROIN Approved by FDA under NADA #141-324

Learn More About Our PROIN Selection

For dogs experiencing urinary incontinence, PROIN is a prescription urinary medication designed to help restore control and reduce urine leakage. Its active ingredient, phenylpropanolamine hydrochloride, works by increasing urethral tone, helping the urethra retain urine more effectively. The medication is most often recommended for urinary incontinence caused by urethral sphincter hypotonus, also known as urethral sphincter mechanism incompetence (USMI), a condition in which the muscles responsible for controlling urination become weakened.

PROIN’s history is rooted in a simple goal: give veterinarians and pet parents an effective means to manage canine urinary incontinence. The brand has relied on numerous controlled studies to build its clinical foundation. The original PROIN Chewable Tablets were approved by the U.S. Food and Drug Administration (FDA) in 2011. The brand’s next major milestone came in 2019, when the FDA approved PROIN ER, an extended-release formulation designed to provide the same active ingredient in a convenient once-daily tablet.

Helping your canine manage urinary incontinence and leakage is easier with our selection of PROIN medications. We offer the brand’s two formulations: PROIN® Chewable Tablets (25 mg, 50 mg and 75 mg strengths, with 60- and 180-count options available) and PROIN ER™ (18 mg, 38 mg, 74 mg and 145 mg strengths, with 30- and 90-count bottles available). Both options are intended for oral use in dogs only and require a veterinary prescription. Consult your vet to determine if PROIN is right for your dog, and visit your local Tractor Supply store or shop online to discover more canine health and wellness supplies and medications.