Maropitant Citrate Tablets are used for the prevention of vomiting in dogs. Maropitant citrate is a non-drowsy antiemetic medication formulated for dogs over the age of 16 weeks. Maropitant citrate is used for the treatment of acute vomiting and vomiting associated with motion sickness in pets, offering broad-spectrum efficacy. It's prescription only and FDA approved.How it Works

Maropitant is a neurokinin 1 (NK1) receptor antagonist which acts by inhibiting the binding of substance P, a neuropeptide of the tachykinin family. Substance P is found in significant concentrations in the nuclei comprising the emetic center and is considered the key neurotransmitter involved in emesis.1 By inhibiting the binding of substance P within the emetic center, maropitant provides broad-spectrum effectiveness against neural (central) and humoral (peripheral) causes of vomiting.

Special Precautions

WARNINGS: Not for use in humans. Keep out of the reach of children. In case of accidental ingestion, seek medical advice. Topical exposure may elicit localized allergic skin reactions in some individuals. Repeated or prolonged exposure may lead to skin sensitization. Wash hands with soap and water after administering drug. Maropitant Citrate is also an ocular irritant. In case of accidental eye exposure, flush with water for 15 minutes and seek medical attention. Keep Maropitant Citrate Tablets in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. In puppies younger than 11 weeks of age, histological evidence of bone marrow hypocellularity was observed at higher frequency and greater severity in puppies treated with Maropitant Citrate compared to control puppies. In puppies 16 weeks and older, bone marrow hypocellularity was not observed (see ANIMAL SAFETY). PRECAUTIONS: The safe use of Maropitant Citrate tablets has not been evaluated in dogs used for breeding, or in pregnant or lactating bitches. The safe use of Maropitant Citrate has not been evaluated in dogs with gastrointestinal obstruction, or dogs that have ingested toxins. Use with caution in dogs with hepatic dysfunction because Maropitant Citrate is metabolized by CYP3A enzymes (see Pharmacokinetics).Use with caution with other medications that are highly protein bound. The concomitant use of Maropitant Citrate with other protein bound drugs has not been studied in dogs. Commonly used protein bound drugs include NSAIDs, cardiac, anticonvulsant, and behavioral medications.

Overdose Information

Contact your nearest emergency animal hospital.

Side Effects

The following adverse events reported for dogs are listed in decreasing order of frequency: anorexia, depression/lethargy, hypersalivation, vomiting, diarrhea, trembling, ataxia, allergic reactions, weight loss, convulsion, hyperactivity, and panting.

Storage

Store at controlled room temperature 20°-25°C (68°-77°F), excursions permitted to 40°C (104°F).