Piroxicam Capsule is nonsteroidal anti-inflammatory drug (NSAID), prescribed to treat inflammation and pain due to arthritis. Give with food to help reduce stomach upset. Each Piroxicam capsule is sold separately.How it Works

Piroxicam is a non-steroidal anti-inflammatory medication (NSAID). It is a non-selective cyclooxygenase inhibitor (COX) with inhibitory effects on COX-2 and COX-1. COX-1 produces homeostasis-regulating prostaglandins, which allows the kidneys to protect the gastrointestinal tract and respond to hypotension. COX-2 produces the prostaglandins that increase when inflammation occurs. COX-2 is upregulated in some tumor types, such as osteosarcoma, urinary bladder transitional cell carcinoma (TCC), prostatic carcinoma, colorectal tumors, oral squamous cell carcinoma, oral melanoma, mammary tumors, and nasal epithelial tumors.

Special Precautions

• Review your pet's other medications with their veterinarian to determine if those drugs might interact with Piroxicam. These medications include ACE inhibitors (quinapril, benazepril, and enalapril) or diuretics. Piroxicam could interact with other drugs.
• Use cautiously in animals with heart failure.
• Avoid use in animals with a history of high blood pressure, intestinal lining (mucosa) perforation, stomach perforation, inflammation, or bleeding.
• Do not administer to animals with a history of allergy or hypersensitivity to the medication.
• Keep out of reach of animals and children.

Overdose Information

Immediately contact your closest emergency animal hospital or vet.

Side Effects

Potential adverse reactions include:

• Livery injury due to liver enzyme elevation (like other types of NSAID)
• Impaired blood clotting resulting from blood platelet effects
• Decreased kidney function and sudden, severe kidney injury (papillary necrosis)
• Ulcers, especially when used in conjunction with phenylbutazone, aspirin, or corticosteroids like prednisone or cortisone
• Peritonitis caused by intestinal perforation
• Loss of appetite
• Vomiting
• Tarry or dark stools caused by intestinal bleeding
• Intestinal bleeding and ulcers
• Stomach bleeding and ulcers

Some of these reactions may be life-threatening and can occur suddenly.

Storage

Store in a dry and cool environment.

Tips

Administering with food can help lessen the likelihood of stomach upset. This drug works rapidly, within 1 to 2 hours, and clinical sign improvement should follow.