Palladia tablets are indicated for the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs. It cuts off blood supply to the tumor, causing the tumor to shrink or stop growing. Palladia is administered orally to dogs and is available by prescription only in strengths of 10 mg, 15 mg or 50 mg.How it Works

Palladia works by both killing tumor cells and by cutting off blood supply to the tumor. In some dogs, Palladia can cause the tumor to shrink, stop growing, or even disappear.

Special Precautions

• Palladia is for dog use only, not for use in humans.
• Keep Palladia in a secure storage area out of the reach of children.
• Children should not come into contact with the urine, feces and vomit of dogs treated with Palladia.
• Individuals who are pregnant, nursing, or may become pregnant should be particularly careful should they choose to administer the medication and follow all precautions carefully as Palladia prevents the formation of new blood vessels in tumors. Similarly, it may affect blood vessel formation in the developing fetus and may cause birth defects. Accidental ingestion of Palladia by a pregnant woman may have adverse effects on pregnancy.
• If you or a family member accidentally ingest Palladia, seek medical advice immediately. Show the treating physician a copy of the package insert or label. In cases of accidental Palladia ingestion, you may experience gastrointestinal discomfort, including diarrhea and vomiting.

Overdose Information

Contact your closest emergency pet hospital.

Side Effects

Common side effects of Palladia include:

• Diarrhea
• Other gastrointestinal complications

In rare cases, serious and sometimes fatal complications have occurred in dogs treated with Palladia. This includes gastrointestinal perforation; if you suspect this condition in your dog, stop administering the medication and seek treatment.

Storage

Store in a dry and cool environment.

Active Ingredients

PALLADIA, a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK), is the phosphate salt of toceranib. The empirical formula is C22H25FN4O2H3O4P and the molecular weight is 494.46. The chemical name is (Z) - 5 - [(5 - Fluoro - 2 - oxo - 1,2 - dihydro - 3H - indol - 3 - ylidene)methyl] - 2,4 - dimethyl - N - (2 - pyrrolidin - 1 - ylethyl) - 1H - pyrrole - 3 - carboxamide phosphate. Toceranib phosphate is a small molecule with an indolinone chemical structure.

Tips

Always wear gloves when handling Palladia and wash your hands after administering the medication to your dog.