Shown to be effective for the vaccination of healthy cattle 3 months of age or older against respiratory disease and abortion due to infectious bovine rhinotracheitis (IBR), respiratory disease and fetal infection, including persistently infected calves due to bovine virus diarrhea virus (BVD) Types 1 and 2, bovine respiratory syncytial virus (BRSV), parainfluenza 3 virus (PI3), Mannheimia haemolytica and Pasteurella multocida. Respiratory duration of immunity has been shown to be at least 1 year for IBR and BVD (Types 1 and 2) and at least 16 weeks for Mannheimia haemolytica and Pasteurella multocida. Reproductive duration of immunity has been shown to be at least 217 days for IBR and at least 206 days for BVD (Types 1 and 2). Duration of immunity for BRSV and PI3 has not been established. Respiratory and reproductive efficacy and duration of immunity has been demonstrated against disease caused by the BVD Type 1b strain. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Vaccine