*For the treatment and control of the Gulf Coast Tick (Amblyomma maculatum), Deer Tick (Ixodes scapularis), American Dog Tick (Dermacentor variabilis), Lone Star Tick (Amblyomma americanum), Brown Dog Tick (Rhipicephalus sanguineus), and Asian Longhorn Tick (Haemaphysalis longicornis). †Studies to support FDA approval showed that 1 dose provided 100% protection against heartworm disease. ‡Simparica Trio starts killing fleas within 4 hours. §For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and treatment of hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. Indicated for the prevention of Dipylidium caninum (tapeworm) infections, by killing fleas.

IMPORTANT SAFETY INFORMATION

Simparica Trio

Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaTrioPI.com.

REFERENCES

1. Data on file. ZMR: Kynetec PetTrack US FTH National Data January 10, 2025.
2. Simparica Trio - 15M Dogs and Counting, PetTrak Kynetec Veterinary Channel Review Q4, 2024.

Simparica

For a prescription chewable brand focused on protecting the overall health of your four-legged best friend, look no further than Simparica and Simparica Trio. The Simparica family includes monthly chewables for tick and flea coverage, plus combination options that can support a broader parasite prevention plan when your veterinarian recommends it. Tractor Supply proudly offers Simparica and Simparica Trio products for dogs – learn more about what these have to offer and what you can find in our stock. 

Simparica: Enduring Protection for Your Canine

Tick and flea risks don’t always follow a neat calendar, especially when dogs move between yards, trails and kennels. Simparica was FDA-approved in 2016 as a once-monthly chewable that delivers fast, persistent flea and tick protection over 35 days. It is also the first flea and tick preventive for dogs to kill six tick species, including hard-to-miss types such as the Gulf Coast tick and the Asian longhorned tick.

In addition, Simparica is FDA-approved to block infections that may cause Lyme disease by killing deer ticks, which adds a clear health-protection angle beyond nuisance bites. The brand also emphasizes no drop-off in effectiveness at the end of the month, which matters when parasite threats still loom right up until day 30 and beyond.

The brand boasts fast start times in studies, including reduced flea activity within 3 hours and killing ticks within 8 hours. Monthly dosing also targets fleas early, including killing them before they can lay eggs, which can help slow down the cycle that turns one flea into many. Simparica products require a prescription and include important safety information for the isoxazoline class (a group of oral and topical ectoparasiticides to control fleas and ticks by ending their life cycles). Consult your veterinarian and consider your dog’s health history before choosing a product.

About Our Simparica and Simparica Trio Selection for Dogs

Parasite protection for your dog starts within. Prescription tablets from Simparica and Simparica Trio provide convenience and effectiveness when it matters most. Oral medications are easy to administer, provide consistent monthly protection and eliminate the worry of messy applications or residues on your dog’s coat. 

Simparica: Flea and Tick Prevention

For companions that need prescription protection in a simple format, Simparica dog flea and tick chewables keep the routine straightforward. Oral flea and tick treatments can be given with or without food, so dosing does not have to line up with meals. It is important to note that Simparica should only be used for dogs 6 months of age and older. Always verify your dog's eligibility with your veterinarian before requesting a prescription.

Simparica Trio: 3-in-1 Flea, Tick and Heartworm Prevention

Simparica Trio is a 3-in-1 product, making it ideal when your veterinarian recommends broader coverage beyond flea and tick prevention. The triple-action protection works against worms, ticks and fleas. It combines sarolaner (for ticks and fleas), moxidectin (for heartworm) and pyrantel (for hookworms/roundworms). Simparica Trio is safe for adult canines and puppies as young as 8 weeks old, weighing at least 2.8 lb., and works for 30 days. Speak to your veterinarian to confirm it is safe based on your dog's weight, age and health needs. 

Discover Simparica Dog Products at Tractor Supply 

A parasite plan works best when it is easy to follow, and the Simparica brand family centers on monthly chewable dosing that keeps dogs covered from within. After getting a prescription from your veterinarian, you can find the right Simparica option for your dog on our website or at your local Tractor Supply store.