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[Home](https://www.tractorsupply.com/tsc/cms/life-out-here) 2. [The Barn](https://www.tractorsupply.com/tsc/cms/life-out-here/the-barn) 3. [Horse](https://www.tractorsupply.com/tsc/cms/life-out-here/the-barn/horse) 4. Lyme Disease in Horses # Understanding Lyme Disease in Horses Sep 30, 2026 [Efrem Hunter, DVM](https://www.tractorsupply.com)  # __Understanding Lyme Disease in Horses__ Lyme disease is often associated with humans and dogs, but it can also affect horses and should not be overlooked. Caused by the bacterium *Borrelia burgdorferi* and transmitted through tick bites, Lyme disease presents unique challenges due to its subtle, wide-ranging symptoms. From unexplained lameness and behavioral changes to performance issues and other symptoms, your horse’s well-being is at risk, making it critical to seek an accurate diagnosis and proper treatment from a veterinarian. #### Key Takeaways - Lyme disease is caused by a tick-borne bacterium (*Borrelia burgdorferi*) and can be difficult to detect due to a range of subtle symptoms. - Horses become infected through tick bites, and ticks carrying Lyme disease acquire the bacterial infection from feeding on small mammals (hosts). - Early diagnosis and treatment greatly improve the chances of recovery from equine Lyme disease. - Consistent prevention and veterinary guidance are critical for protecting your horse and maintaining long-term health. ### __What Is Lyme Disease, and How Does It Affect Horses?__ Equine Lyme disease is a bacterial infection caused by *Borrelia burgdorferi*, a tiny, coil-shaped organism. It is transmitted through the bite of infected ticks – notably blacklegged ticks, also known as deer ticks. Therefore, tick populations in the United States play a major role in the prevalence of the disease in horses. Ticks are found throughout the country, with deer tick populations most commonly distributed across the Northeast, Pacific Coast and Midwest, particularly in wooded, grassy and pasture environments where horses often graze. Horses in these parts are at higher risk of contracting Lyme disease. When a horse is bitten by an infectious tick, the bacteria can enter its bloodstream and spread throughout its body, potentially affecting the joints, nervous system and overall health. Many infected horses may not show obvious signs at first, while others develop symptoms gradually. In more advanced cases, the infection can bring on symptoms rapidly, even leading to death, making early intervention and veterinary examination crucial. Small mammals, such as mice and other wildlife, play a key role in the cycle of infection. These animals act as natural reservoirs for *Borrelia burgdorferi*, meaning ticks become infected when they feed on them. The ticks then pass Lyme disease to horses. However, this does not happen right away, typically taking at least 18 hours for the bacterial organisms to modify to enter the horse’s body. Lyme disease cannot be transmitted from horse to horse; therefore, they are considered “incidental or dead-end” hosts, similar to Lyme disease in humans.  __Expert tip:__ Regularly inspect your horse for ticks, paying close attention to the mane, tail, underbelly and between the legs and removing any promptly. Reducing tick exposure early is one of the simplest and most effective ways to lower the risk of equine Lyme disease. ### __What Are the Symptoms of Equine Lyme Disease?__ The symptoms of Lyme disease in horses can be varied, subtle and inconsistent, making early recognition difficult at times. In many cases of equine Lyme disease, signs develop gradually, taking anywhere from a few weeks to several months, and they may be mistaken for other health issues. Some horses may show no obvious symptoms (asymptomatic), while others experience noticeable changes in behavior and performance. The most common signs include: - Shifting or unexplained lameness, potentially leading to laminitis - Stiffness or reluctance to move - Sensitivity to touch, especially along the back or neck - Behavioral changes and irritability - Decreased performance or unwillingness to work - Lethargy or reduced energy levels - Weight loss or poor body condition - Muscle soreness - Joint swelling and pain - Low-grade fever It is important to note that many of the signs associated with Lyme disease in horses, including shifting lameness, stiffness and behavioral changes, are nonspecific and can be caused by numerous other conditions. The American Association of Equine Practitioners (AAEP) notes that limited evidence exists to document stiffness, lameness, and malaise as direct results of *Borrelia burgdorferi* infection, though these signs are possible. A thorough veterinary evaluation to rule out other causes is essential before attributing them to Lyme disease. In some cases, Lyme disease can progress to cause more specific and serious complications, though these are less common than the general signs described above. The following conditions have been documented in association with Lyme disease in horses and highlight why prompt diagnosis and treatment are important: #### Uveitis This form of inflammation within the eye is one of the more concerning complications that can arise from Lyme disease. Horses may develop redness, excessive tearing or discharge, cloudiness or sensitivity to light. If left untreated, uveitis can lead to vision impairment or even blindness within a month.  #### Neuroborreliosis When *Borrelia burgdorferi* infects a horse’s central nervous system, neuroborreliosis is a real concern. It can result in several neurological symptoms, such as ataxia (incoordination), muscle tremors, behavioral changes, head tilt, irregular eye movements, unexplained circling, dysphagia (trouble swallowing) and respiratory distress.  #### Bursitis In horses with Lyme disease, bursae (fluid-filled sacs that cushion joints and reduce friction) can become inflamed, known as bursitis. This complication may present as swelling, heat and/or pain around affected joints, contributing to lameness and limited mobility. #### Cutaneous Pseudolymphoma Appearing as superficial bumps on the skin where the tick attached to the horse, cutaneous pseudolymphoma is a rare skin-related manifestation associated with Lyme disease. While typically benign, these lesions can be mistaken for more serious conditions, making proper diagnosis by a veterinarian critical.  __Expert tip:__ If you notice vague, shifting symptoms, particularly intermittent lameness combined with unusual behavior, do not wait for signs to become severe. Early veterinary evaluation and testing make treatment more effective, leading to better outcomes.  ### __How Do Veterinarians Diagnose Lyme Disease?__ Diagnosing Lyme disease in horses can be challenging, as many cases do not involve obvious clinical symptoms. When symptoms are present, they often overlap with several other conditions, such as lameness issues, neurological disorders or general performance decline. For these reasons, veterinarians only tentatively diagnose equine Lyme disease when clinical signs are present, diagnostic tests come back positive and all other potential causes of a horse’s symptoms are ruled out. It is important to note that routine serological testing of clinically healthy horses is not recommended by the AAEP, nor is treatment of horses that test positive but show no clinical signs. A positive antibody result alone does not confirm active disease and does not justify treatment. Testing and treatment decisions should be made by a veterinarian based on clinical signs, history and test results interpreted together.  The diagnostic process generally involves a combination of the following: #### Clinical Signs and Medical History Your vet will likely begin with a thorough review of the horse’s symptoms and history, looking for signs of lameness, stiffness, changes in behavior and performance decline. They will also consider the horse’s environment, exposure to ticks and any history of tick bites. While this alone is not enough to confirm equine Lyme disease, vets use this information to guide further testing.  #### Blood Testing The most common diagnostic tool for confirming Lyme disease is a blood test (serology) that looks for antibodies against *Borrelia burgdorferi*. These tests, including the IDEXX SNAP rapid diagnostic tool, indicate whether the horse has been exposed to the bacteria. Antibodies can take up to 3 weeks to appear in the blood, which is why some vets recommend testing up to 8 weeks after exposure and annually in regions where ticks are common. Because antibodies can remain in the system after exposure or past infection, a positive result does not necessarily mean the disease is currently active. Therefore, vets will interpret results carefully in context with clinical signs. #### Specialized Testing In some cases, additional, more advanced testing is called for to provide a clearer picture of the infection, such as:  - __Western blot:__ This detects antibodies to specific proteins of *Borrelia burgdorferi*, helping differentiate between exposure and possible active infection. - __Multiplex antibody assays:__ These tests, most notably the Cornell Equine Lyme Multiplex Assay, measure the antibodies of specific Lyme-related proteins to improve accuracy and reduce false positives from past exposure. - __Polymerase chain reaction (PCR) test:__ This is used to detect bacterial DNA directly in blood or tissue samples. - __Cytology:__ Vets examine cells from affected tissues or fluids under a microscope to rule out other causes of inflammation or infection mimicking Lyme disease symptoms. - __Histopathology:__ This involves the microscopic examination of tissue samples to detect inflammation patterns or structural changes consistent with chronic infection or immune response. #### Prometheus Testing Samples or culture swabs are sometimes taken from a horse’s brain or central nervous system in the rare case where the animal perishes or is euthanized and tested for Lyme disease. While blood tests measure exposure, postmortem testing of tissues (brain/spinal fluid) is the most reliable way to confirm an active, severe infection, and it is often the only way to confirm a diagnosis of neurologic Lyme disease (neuroborreliosis). __Expert tip:__ Keep a detailed record of your horse’s symptoms, behavior changes and performance levels over time. When paired with advanced testing results, the timeline this information creates can be insightful for your vet in distinguishing between past exposure and an active Lyme disease case.  ### __How Do Veterinarians Treat Lyme Disease in Horses?__ Treating Lyme disease typically involves a course of tetracycline-class antibiotics for 30 to 60 days, depending on the severity of the infection and how early treatment was initiated. Veterinarians most commonly prescribe oral [doxycycline](https://www.tractorsupply.com/tsc/product/doxycycline-oral-suspension-25-mg-5-ml-60-ml-2545097) or [minocycline](https://www.tractorsupply.com/tsc/product/minocycline-tablet-100-mg-2544664) for 30 to 45 days, or intravenous Oxytetracycline for up to 30 days in more severe cases, sometimes followed by a course of oral [antibiotics](https://www.tractorsupply.com/tsc/catalog/horse-antibiotics) to complete treatment. Your veterinarian will determine the appropriate protocol and duration based on your horse’s individual response.   In addition to antibiotics, vets often recommend supportive care to help manage symptoms and improve the horse’s comfort. This can include [anti-inflammatory medications](https://www.tractorsupply.com/tsc/catalog/horse-anti-inflammatory-pain-medications), such as [flunixin meglumine (Banamine®)](https://www.tractorsupply.com/tsc/product/banamine-%28flunixin-meglumine%29-injection-2544621) and [phenylbutazone (butequine™),](https://www.tractorsupply.com/tsc/product/butequine-%28phenylbutazone%29-paste-for-horses-60-ml-2544397) to reduce joint pain and stiffness, as well as adjustments to routines and workloads during recovery. Horses with more advanced symptoms may require closer monitoring and a more intensive treatment plan that can include acupuncture, herbal therapy and chiropractic care. Treatment is deemed successful once symptoms improve and the horse returns to its normal state, though recovery timelines can vary widely. Some animals begin to show improvement within a few days of starting treatment, while others may take weeks to fully regain normal function. Regular follow-up with your vet is essential to track progress and ensure the infection has been effectively cleared. __Expert tip:__ Early intervention is key to treating Lyme disease. Horses treated in the early stages of Lyme disease generally have a much better prognosis and a smoother recovery than when treatment is delayed. Always consult a vet if you suspect Lyme disease to help prevent the risk of long-term complications. ### __Can Equine Lyme Disease Be Prevented?__ While it is not possible to eliminate the risk of Lyme disease entirely, several effective strategies can significantly reduce it. Because the infection is transmitted through tick bites, prevention focuses on limiting exposure and managing environments where ticks can be found.  Tick prevention practices can include: #### Tick Checks One of the most effective preventative measures is consistent tick control through regular checks, especially if you live in an area known for tick exposure. You should check your horse daily for ticks, especially around high-risk areas, such as the mane, tail, under the jaw, under the belly and between the legs. Prompt removal of any attached ticks with a tick removal tool or tick twister significantly reduces the likelihood of disease transmission. #### Pasture and Environmental Management Environmental management also plays a key role in tick prevention. Keeping pastures well-maintained by mowing tall grasses, removing brush or leafy debris and deterring wildlife (potential hosts) helps minimize exposure. Keeping stalls and paddocks well-lit, rotating turnout zones and creating buffers between wooded areas can also be beneficial.  #### Repellents and Tick Control Products Tick repellents designed for horses, combined with fly control dressings such as [horse fly masks](https://www.tractorsupply.com/tsc/catalog/horse-fly-masks), [sheets](https://www.tractorsupply.com/tsc/catalog/horse-fly-sheets) and [boots](https://www.tractorsupply.com/tsc/catalog/horse-fly-boots), provide additional layers of protection. Several [horse fly concentrates](https://www.tractorsupply.com/tsc/catalog/horse-fly-control-concentrates), [spot-on lotions](https://www.tractorsupply.com/tsc/catalog/horse-fly-spot-on-lotions), [sprays and wipes](https://www.tractorsupply.com/tsc/catalog/horse-fly-sprays-wipes), including [Farnam Endure](https://www.tractorsupply.com/tsc/product/farnam-endure-fly-spray-32-oz) and [Pyranha® Wipe N’ Spray](https://www.tractorsupply.com/tsc/product/pyranha-wipe-n-spray-for-horses-1-qt), are also effective against ticks. Additionally, use horse-safe outdoor yard treatments to help reduce tick populations in high-traffic areas.   #### Vaccination and Oral Dewormers In regions where Lyme disease is especially prevalent, veterinarians may recommend [vaccination](https://www.tractorsupply.com/tsc/catalog/horse-vaccines) as part of your tick prevention plan. In regions where Lyme disease is especially prevalent, some veterinarians may consider off-label use of canine Lyme vaccines in horses. There is no U.S. Department of Agriculture (USDA)-approved or licensed Lyme vaccine for horses, and the use of canine vaccines in equine patients is not standard practice. If this approach is being considered, it should only be done under the direct guidance of a veterinarian with experience in Lyme-endemic areas and fully informed consent.  Certain oral [dewormers](https://www.tractorsupply.com/tsc/catalog/horse-dewormers), specifically ivermectin and moxidectin, kill ticks that have attached and are feeding on the horse. These strategies can help but should not be used as standalone prevention strategies. __Expert tip:__ While every horse and environment is unique, the best defense is a multi-pronged prevention plan. Also, consistency is key: regular preventive practices are far more effective than occasional efforts. ### __Frequently Asked Questions About Lyme Disease in Horses__ __Can horses recover fully from Lyme disease?__ Yes, many horses make a full recovery, especially when the infection is caught early and treated correctly. However, in more severe cases, or if treatment is delayed, horses may experience lingering symptoms that require ongoing management.  __Can Lyme disease be passed from horse to horse?__  No, Lyme disease is not contagious among horses. It is only transmitted through the bite of infected ticks, but horses in the same environment can become infected if ticks are present.  __Do fly sprays and repellents really help against ticks?__  Yes, many horse fly control products are formulated to deter ticks when used consistently. While they do not promise complete protection, they are generally used as part of a broader prevention plan.  ### __Equine Lyme Disease Recovery and Prevention at Tractor Supply’s Horse Pharmacy__ Life Out Here comes with its share of challenges, and Lyme disease in horses is one that demands awareness, prevention and timely action. With the right [prescriptions](https://www.tractorsupply.com/tsc/catalog/horse-prescriptions) and products from [Tractor Supply's horse pharmacy](https://www.tractorsupply.com/tsc/catalog/horse-care?filter=2b1%7CY), you can help ensure your herd stays healthy, happy and thriving. Get the top deals, latest trends and more Sign up for emails from Tractor Supply today. 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