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[Home](https://www.tractorsupply.com/tsc/cms/life-out-here) 2. [The Barn](https://www.tractorsupply.com/tsc/cms/life-out-here/the-barn) 3. [Horse](https://www.tractorsupply.com/tsc/cms/life-out-here/the-barn/horse) 4. Borna Disease in Horses # Borna Disease in Horses: What Owners Need to Know About This Fatal Condition Sep 30, 2026 [Efrem Hunter, DVM](https://www.tractorsupply.com)  # __Borna Disease in Horses__ There is a lot that goes into [equine health and wellness](https://www.tractorsupply.com/tsc/catalog/horse-health-wellness), including awareness of serious threats and health conditions. Borna disease is one such condition, a rare but often fatal neurological illness that affects horses with little warning and devastating consequences. While the condition is geographically concentrated in Central Europe, it is still crucial for North American horse owners to understand the disease and prioritize prevention through environmental control. Learn more about Borna disease, the early signs that can be easily overlooked or mistaken for other issues and prevention strategies.  #### Key Takeaways - Equine Borna disease is a rare but often life-threatening neurological illness that affects the brain and central nervous system in horses. - Clinical signs may take months to appear after infection, making early detection very difficult. - Symptoms typically begin subtly but quickly progress to debilitating neurological issues. - Diagnosis often requires a combination approach, including clinical evaluation, lab testing and postmortem confirmation. - There is currently no established vaccine or treatment for Borna disease in North America, so prevention is the most effective strategy. ### __What Is Borna Disease in Horses?__ Borna disease is a rare but severe neurological condition caused by the Borna disease virus 1 (BoDV-1), a pathogen that primarily targets the brain and central nervous system of warm-blooded animals. Classical equine Borna disease caused by BoDV-1 has not been documented in horses in the United States. The disease is geographically concentrated in specific parts of Central Europe – primarily Germany, Switzerland, Austria and Liechtenstein – where it is considered endemic. There are no licensed vaccines nor established treatment protocols for equine Borna disease in North America. Related borna viruses have been identified in North American wildlife, but classical equine BoDV-1 is not established in this region. Horse owners should remain aware of the condition, particularly those importing animals from or traveling through endemic European regions.  What makes the virus concerning is its ability to cause inflammation of the brain, triggering an immunopathological reaction that causes non-purulent meningoencephalomyelitis. This disrupts normal brain function, resulting in a range of troubling neurological symptoms that can progress rapidly. Although the disease is considered uncommon, knowledge of it is still crucial, as it often leads to death in horses once clinical signs appear.  Borna disease in horses is believed to be linked to shrews and some rodents, which serve as reservoir hosts. Transmission typically occurs when the virus-infected small mammal’s saliva, urine or feces is ingested or inhaled. Horses are known as accidental hosts, meaning they become infected through environmental exposure rather than direct transmission from other horses. __Expert tip:__ Consider keeping a health log for your horse and note even small changes in behavior, appetite or movement patterns. Early signs of neurological issues, such as those seen in Borna disease cases, can be easy to miss day-to-day but become more obvious when tracked over time.  ### __What Are Symptoms of Borna Disease in Horses?__ The symptoms of Borna disease can be subtle at first, but they typically advance into noticeable neurological dysfunction. One of the challenges with this viral infection, besides its symptoms resembling those of other equine encephalitic diseases, is that clinical signs often appear after a long incubation period. Because the virus moves slowly along neurons, you may not notice anything wrong with your horse until weeks to months after initial exposure, making it difficult to trace the source of the infection. Early-stage symptoms can include:  - Mild lethargy or a decrease in energy - Reduced appetite - Low-grade fever - Subtle changes in behavior, including withdrawal from normal activity or unusual quietness - A slight sensitivity to touch As the disease progresses, more obvious neurological symptoms start to appear, such as: - A noticeable lack of coordination (ataxia) - Stumbling or trouble walking in a straight line - Demonstrating strange behaviors, such as head-pressing, circling or standing in dark corners - Muscle tremors or twitching - Vision impairment, abnormal eye responses or blindness - Seizures - Paralysis or an inability to stand __Expert tip:__ Do not wait for multiple symptoms to appear before taking action. Even a single early sign, such as mild lethargy or unusual behavior, can indicate something more serious is happening. Prompt evaluation from a veterinarian offers the best prognosis and guidance for making informed decisions.  ### __How Do Veterinarians Diagnose Borna Disease in Horses?__ For veterinarians, diagnosing Borna disease in horses can be a challenge, mainly in the disease’s early stages when symptoms are vague and overlap with other conditions. There is no single, definitive test that confirms Borna disease in live animals, and therefore, animal health professionals rely on a combination of the following: #### Clinical Evaluation Typically, a vet will begin diagnosing Borna disease by conducting a thorough physical and neurological exam. The veterinarian will pay close attention to the horse’s behavior, coordination, reflexes and overall responsiveness to specific cues. Certain signs, such as ataxia, abnormal posture and altered mental state, raise suspicion of a central nervous system disorder, warranting further, more in-depth analysis.  #### Diagnostic Testing To pinpoint the underlying causes of symptoms and neurological dysfunction, vets may perform several tests, including: - __Cerebrospinal fluid (CSF) analysis:__ This detects abnormalities in the brain and spinal cord. - __Polymerase chain reaction (PCR) testing:__ This looks for viral genetic material. - __Serological testing (blood tests):__ These measure antibody levels over time to assess inflammation and potential recent infection. - __Enzyme-linked immunosorbent assay (ELISA):__ An ELISA detects antibodies against the Borna disease in the blood, indicating exposure to the virus. Though a positive result confirms prior exposure only, not necessarily active disease, it should be interpreted in conjunction with clinical findings and other diagnostic results. While these tests can support a diagnosis, they do not always provide a definitive answer, and false positives can occur. Furthermore, a positive antibody result confirms exposure to the virus, not active disease or confirmed carrier status. In endemic areas, antibodies have been detected in clinically healthy horses, but the significance of this finding is not settled in the literature. A positive serological result must be interpreted alongside clinical signs and other diagnostic findings – it is not sufficient for a definitive diagnosis on its own. #### Postmortem Confirmation In most cases, a definitive diagnosis of Borna disease in horses is confirmed only after death. Specialized laboratory testing confirms the diagnosis and often includes: - __Histopathology:__ This test involves examining brain tissue at a microscopic level to identify characteristic lesions associated with Borna disease, such as non-suppurative inflammation, neuronal degeneration and the presence of Joest-Degen inclusion bodies. - __Immunohistochemistry:__ This technique uses specific antibodies to detect Borna disease viral antigens within tissue samples, confirming the infection. __Expert tip:__ Try to keep your horse’s environment as stable as possible while neurological testing is underway. Sudden changes in handling or routine can sometimes worsen visible neurological signs, making it more difficult for the vet to assess baseline behavior in cases of suspected Borna disease. ### __How Do You Treat Borna Disease in Horses?__ Currently, there is no established treatment protocol in North America for equine Borna disease, making management particularly difficult with no vaccine or cure available. Treatment is largely supportive, aimed at improving comfort and managing symptoms associated with the disease. This may include: - [__Anti-inflammatory medications__](https://www.tractorsupply.com/tsc/catalog/horse-anti-inflammatory-pain-medications)__:__ Nonsteroidal anti-inflammatory drugs (NSAIDs), such as [flunixin meglumine (Banamine®)](https://www.tractorsupply.com/tsc/product/banamine-%28flunixin-meglumine%29-injection-2544621), and corticosteroids, including the [VetOne® dexamethasone injection](https://www.tractorsupply.com/tsc/product/dexamethasone-injection-2-mg-ml-100-ml-2544699), help reduce brain inflammation and alleviate discomfort. - __Intravenous (IV) fluids:__ Administered fluids provide hydration and help maintain electrolyte balance, especially in horses that are not eating or drinking. - __Anti-seizure medications:__ Anti-seizure medications – prescribed and administered by a veterinarian and only available via veterinary prescription – may be administered to help control seizures, reduce anxiety and manage muscle tremors. - __Nutritional support__: Assisted feeding, including the use of a feeding tube or soft feed, ensures the horse receives adequate calories and nutrients during recovery. Despite best efforts, the prognosis of Borna disease in horses is often poor once clinical signs are advanced, and many affected horses do not recover. In less severe cases, some horses may gradually recover over several weeks or months, though lingering neurological deficits are common. However, if a horse remains severely recumbent, aggressive or unable to eat or drink safely, owners may need to make the difficult yet humane decision to euthanize the animal.  __Expert tip:__ Close veterinary monitoring is essential, as the disease can progress rapidly and requires adjustments in supportive care based on the horse’s condition.  ### __Can Borna Disease Be Prevented?__ With treatment options limited to managing symptoms and no [vaccine](https://www.tractorsupply.com/tsc/catalog/horse-vaccines) available, reducing environmental exposure remains the most effective protective measure. Key strategies for preventing equine Borna disease focus on environmental control, and they should include: - Securing [horse feed](https://www.tractorsupply.com/tsc/catalog/horse-feed) and [hay](https://www.tractorsupply.com/tsc/catalog/hay-forage) in sealed metal storage containers to prevent contamination - Maintaining clean, well-sealed stable environments, using barn sealants, hardware cloth and vent covers to block shrew and rodent entry - Controlling rodent and wildlife access to barns and [feed storage](https://www.tractorsupply.com/tsc/catalog/feed-storage-scoops) areas with bait stations and snap traps, including [Victor®](https://www.tractorsupply.com/tsc/brand/Victor+Pest/animal-rodent-control) and [JT Eaton®](https://www.tractorsupply.com/tsc/brand/jt+eaton/animal-rodent-control) rodent control solutions - Practicing proper hygiene when handling feed and [bedding](https://www.tractorsupply.com/tsc/catalog/horse-bedding) - Monitoring horses closely for neurological changes __Expert tip:__ When creating a Borna disease prevention plan, focus first on overlooked entry points. Even well-maintained barns can allow access for small mammals, such as shrews or rodents, through inconspicuous gaps. A monthly walk-through to check seals, vents and storage integrity can be more effective than occasional large cleanouts after problems appear.  ### __Frequently Asked Questions About Borna Disease in Horses__ __Is Borna disease contagious between horses?__  No, Borna disease is not typically spread directly from horse to horse. Infection is believed to occur mainly through exposure to the horse’s environment, often linked to small mammals, including shrews and rodents, that can carry the virus. __How common is Borna disease in horses?__  Equine Borna disease is considered very rare, with most cases historically being reported in parts of Central Europe. However, when it does occur, the results are often fatal.  __Can a horse recover from Borna disease?__  Unfortunately, it is not likely. Because the disease affects the animal’s central nervous system, many cases progress rapidly and have a poor prognosis, even with aggressive care. In most cases, humane euthanasia is elected due to debilitating symptoms that impact quality of life, including blindness, convulsions and inability to stand. In less severe cases, however, recovery is possible, though lingering symptoms are common. ### __Find Horse Medicines at Tractor Supply’s Horse Pharmacy__ Borna disease in horses remains a rare but serious neurological condition that often has devastating consequences once clinical signs are present. Early recognition and veterinary involvement are essential, but unfortunately, the condition has no definitive cure. [Tractor Supply’s horse pharmacy](https://www.tractorsupply.com/tsc/catalog/horse-care?filter=2b1%7CY) offers horse owners and handlers a variety of prescriptions to help keep animals comfortable, manage symptoms and maintain quality of life. 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